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Clinical Blood Assay Executive Summary
 



Clinical Blood Assay Executive Summary

Name: Clinical Blood Assay
Elevator Pitch: Technology for evaluating, monitoring, and dosing therapeutics for the treatment of bleeding and thrombotic disorders
Department: Chemical & Biological Engineering, Colorado School of Mines

Please click here for a PDF of the Clinical Blood Assay Executive Summary

Background
A team of Mines faculty has developed a technology for evaluating, monitoring, and dosing therapeutics for the treatment of bleeding and thrombotic disorders. As part of this research, an in vitro vascular injury model called the microfluidic flow assay (MFA) was created.

The MFA consists of a series of microfluidic channels with characteristic sizes of ~100 μm, which run perpendicular to micropatterned prothrombotic molecules that trigger clotting, such as collagen and tissue factor. This technology captures the dynamics of clot formation under flow, which is currently absent in conventional clotting assays. Within a single assay, it can flow blood over the range of physiologic shear stresses in different channels and monitor the growth and stability of each clot in real-time with various microscopy methods. To date, research has shown that the MFA can be used as a diagnostic tool to detect dysfunctions on platelet function and coagulation. The research team is currently in the midst of a large clinical trial (600 patients) of the MFA for diagnosing bleeding disorders at the Hemophilia and Thrombosis Center at the University of Colorado Hospital.

The Innovation Center of the Rockies is recruiting Advisors to understand the commercial potential of the MFA technology and develop a commercialization strategy to bring it to market.

Some of the desired experience we are recruiting for;
•Testing assays
•Blood diagnostics
•Bleeding disorders
•Medical device development

Technology Benefits
•MFA combines the hemodynamics found in animal studies with human blood
•Captures the dynamics of clot formation under flow
•Within a single assay, flow blood over the range of physiologic shear stresses in different channels and monitor the growth and stability of the each clot in real-time

Keywords
Medical device, blood, blood clotting, bleeding disorders, diagnostic, anticoagulant, thrombotic

To Indicate an Interest or for More Information: 303.444.2111 or Eric@InnovationCenteroftheRockies.com. Please include a copy of your resume.